NSF 16-607: Collaborative Research in Computational Neuroscience (CRCNS)

Program Solicitation NSF 16-607

		National Science Foundation Directorate for Computer & Information Science & Engineering Directorate for Biological Sciences Directorate for Social, Behavioral & Economic Sciences Directorate for Mathematical & Physical Sciences Directorate for Engineering Office of International Science and Engineering
		National Institutes of Health     National Institute of Neurological Disorders and Stroke     National Institute of Mental Health     National Institute on Drug Abuse     National Eye Institute     National Institute on Deafness and Other Communication Disorders     National Institute of Biomedical Imaging and Bioengineering     National Institute on Alcohol Abuse and Alcoholism     Eunice Kennedy Shriver National Institute of Child Health and Human Development     National Center for Complementary and Integrative Health
		Federal Ministry of Education and Research, Germany
		French National Research Agency
		United States-Israel Binational Science Foundation

Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

     December 19, 2016

Important Information And Revision Notes

This solicitation extends the Collaborative Research in Computational Neuroscience program for FY2017. Please note the following administrative revisions and clarifications:

• Data Sharing Proposals will be considered by all participating funders.
• Results from prior NSF and/or CRCNS support must address sharing of data, software, and/or other resources under prior support (see Section V.A of this solicitation).
• NIH review criteria have been updated (Section VI.A), reflecting NIH guidance on rigor and reproducibility (http://grants.nih.gov/reproducibility).
• Letters of collaboration should be limited to the one-sentence format recommended in Section V.A.

Any proposal submitted in response to this solicitation should be submitted in accordance with the revised NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 17-1), which is effective for proposals submitted, or due, on or after January 30, 2017.

Summary Of Program Requirements

General Information

Program Title:

Collaborative Research in Computational Neuroscience (CRCNS)
Innovative Approaches to Science and Engineering Research on Brain Function

Synopsis of Program:

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines.

Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), and the United States-Israel Binational Science Foundation (BSF) support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.

Two classes of proposals will be considered in response to this solicitation:

Research Proposals describing collaborative research projects; and

Data Sharing Proposals to enable sharing of data and other resources.

Domestic and international projects will be considered. As detailed in the solicitation, international components of collaborative projects may be funded in parallel by the participating agencies. Specific CRCNS opportunities for parallel funding are available for bilateral US-German Research Proposals, US-German Data Sharing Proposals, US-French Research Proposals, US-French Data Sharing Proposals, US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, and multilateral proposals involving the United States and 2 or more partnering countries (Germany, France, and/or Israel).

Appropriate scientific areas of investigations may be related to the interests of any of the participating funding organizations. Questions concerning a particular project's focus, direction and relevance to a participating funding organization should be addressed to the appropriate person in the list of agency contacts found in Section VIII of the solicitation.

NSF will coordinate and manage the review of proposals jointly with participating domestic and foreign funding organizations, through a joint panel review process used by all participating funders. Additional information is available in Section VI of the solicitation.

Cognizant Program Officer(s):

Please note that the following information is current at the time of publishing. See program website for any updates to the points of contact.

• Jasmine Owens, CRCNS Administrative Coordinator - NSF; Program Analyst, Division of Information and Intelligent Systems, National Science Foundation, 1125 S, telephone: (703) 292-8377, fax: (703) 292-9073, email: jowens@nsf.gov

• Kenneth Whang, CRCNS Program Coordinator - NSF; Program Director, Division of Information and Intelligent Systems, National Science Foundation, 1125 S, telephone: (703) 292-5149, fax: (703) 292-9073, email: kwhang@nsf.gov

Applicable Catalog of Federal Domestic Assistance (CFDA) Number(s):

• 47.041 --- Engineering
• 47.049 --- Mathematical and Physical Sciences
• 47.070 --- Computer and Information Science and Engineering
• 47.074 --- Biological Sciences
• 47.075 --- Social Behavioral and Economic Sciences
• 47.079 --- Office of International Science and Engineering
• 93.173 --- National Institute on Deafness and Other Communication Disorders
• 93.213 --- National Center for Complementary and Integrative Health
• 93.242 --- National Institute of Mental Health
• 93.273 --- National Institute on Alcohol Abuse and Alcoholism
• 93.279 --- National Institute on Drug Abuse
• 93.286 --- National Institute of Biomedical Imaging and Bioengineering
• 93.853 --- National Institute of Neurological Disorders and Stroke
• 93.865 --- Eunice Kennedy Shriver National Institute of Child Health and Human Development
• 93.867 --- National Eye Institute

Award Information

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 15 to 25 per year

Anticipated Funding Amount: $5,000,000 to $20,000,000

per year, subject to availability of funds

Eligibility Information

Who May Submit Proposals:

The categories of proposers eligible to submit proposals to the National Science Foundation are identified in the NSF Proposal & Award Policies & Procedures Guide (PAPPG), Chapter I.E.

Who May Serve as PI:

There are no restrictions or limits.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or Co-PI: 2

In response to this solicitation, an investigator may participate as PI or Co-PI in no more than two proposals per review cycle. In the event that a PI or Co-PI does appear in either of these roles on more than two proposals, all proposals that include that person as a PI or Co-PI will be returned without review. This limit applies to all PIs and Co-PIs, based inside or outside of the United States.

Proposal Preparation and Submission Instructions

A. Proposal Preparation Instructions

• Letters of Intent: Not required

• Preliminary Proposal Submission: Not required

• Full Proposals:

  • Full Proposals submitted via FastLane: NSF Proposal and Award Policies and Procedures Guide, Part I: Grant Proposal Guide (GPG) Guidelines apply. The complete text of the GPG is available electronically on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=gpg.
  • Full Proposals submitted via Grants.gov: NSF Grants.gov Application Guide: A Guide for the Preparation and Submission of NSF Applications via Grants.gov Guidelines apply (Note: The NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide)

B. Budgetary Information

• Cost Sharing Requirements:

  Cost Sharing is not required under this solicitation.

• Indirect Cost (F&A) Limitations:

  Foreign organizations that do not have a current U.S. federally negotiated indirect cost rate(s) are limited to a de minimis indirect cost rate recovery of 10% of modified total direct costs. Foreign grantees that have a U.S. federally negotiated indirect cost rate(s) may recover indirect costs at the current negotiated rate.

• Other Budgetary Limitations:

  Other budgetary limitations apply. Please see the full text of this solicitation for further information.

C. Due Dates

• Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

       December 19, 2016

Proposal Review Information Criteria

Merit Review Criteria:

National Science Board approved criteria. Additional merit review considerations apply. Please see the full text of this solicitation for further information.

Award Administration Information

Award Conditions:

Additional award conditions apply. Please see the full text of this solicitation for further information.

Reporting Requirements:

Standard NSF reporting requirements apply.

I. Introduction

One of the most exciting and difficult challenges for contemporary science and engineering is to understand complex neurobiological systems, from genetic determinants to cellular processes to the complex interplay of neurons, circuits, and systems orchestrating behavior and cognition. Disorders of the nervous system are also associated with complex neurobiological changes, which may lead to profound alterations at all levels of organization. The computational principles and strategies of the nervous system have implications for biological and engineered systems alike, opening new avenues for discovery, application, and invention.

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding the principles and dynamics of the nervous system. Building on the theory, methods, and findings of computer science, neuroscience, biology, the mathematical and physical sciences, the social and behavioral sciences, engineering, and other fields, computational neuroscience employs a broad spectrum of approaches to study structure, function, organization, and computation across all levels of the nervous system. Advances in computational neuroscience are being accelerated by new methods for integrating and analyzing complex data; conceptual frameworks deriving from many different theoretical sources; and new modalities for large-scale data collection, simulation and modeling, and fine experimental manipulation.

Furthering these advances, collaboration plays a pivotal role. Collaborative research enables close interaction between theory, modeling, simulation and analysis, and experimental neuroscience. This provides a framework for interpretation of empirical data, quantitative hypotheses for empirical testing, and grounding of theories and models in an empirical and evaluation context. International collaborations bring together diverse research perspectives, expand the range of research partnerships, and develop a community of globally engaged scientists and engineers. Sharing of data, software, and other resources provides a powerful modality for larger-scale interaction and collaborative discovery.

Research and research communities supported by the participating funding organizations encompass complementary approaches and investigator communities whose integrative efforts are needed for the advancement of computational neuroscience; thus, cooperation among agencies in this area is appropriate and essential. Through the Collaborative Research in Computational Neuroscience (CRCNS) program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), and the United States-Israel Binational Science Foundation (BSF) support collaborative activities that will span the full spectrum of computational neuroscience research, thereby advancing the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.

The participating funding organizations have released parallel documents with further agency-specific information, referenced in Section VIII of this solicitation.

II. Program Description

Two classes of proposals will be considered in response to this solicitation: Research Proposals describing collaborative research projects; and Data Sharing Proposals to enable sharing of data and other resources. Domestic and international projects will be considered, as detailed in Sections V.A. and VIII of this solicitation.

In general, appropriate scientific areas of investigations may be related to the missions and strategic objectives of any of the participating funding organizations. Some specific examples are given at the end of this section. Questions concerning a particular project's focus, direction and relevance to a participating funding organization should be addressed to the appropriate person in the list of agency contacts.

Each of the funding organizations participating in this program has a commitment to developing and supporting computational neuroscience research for the purpose of advancing the understanding of the neuroscience questions relevant to the missions of the organizations. Proposals selected for funding must be responsive to the mission of a participating funding organization.

Assurance of Innovative Collaborative Research Effort Across Scientific Disciplines: The driving principle behind this program is the recognition that projects crossing traditional academic disciplinary boundaries often bring about increased productivity, creativity, and capacity to tackle major challenges. Collaborative efforts that bring together investigators with complementary experience and training, and deep understanding of multiple scholarly fields, are a requirement for this program and must be convincingly demonstrated in the proposal. A typical research collaboration might involve a computer scientist and a neurobiologist, for example, though note that this solicitation does not prescribe any particular mix of disciplinary backgrounds or scientific approaches. Proposals for research projects should describe collaborations that bring together the complementary expertise needed to achieve significant advances on challenging interdisciplinary problems. Proposals for data sharing should describe resources that respond to the needs of a broad community of investigators to enable wide-ranging research advances.

This program emphasizes innovative research and resources, encouraging the application and development of state-of-the-art computational methods by theorists, computational scientists, engineers, mathematicians, and statisticians to tackle dynamic and complex neuroscience problems.

Computational research supported under this program must relate to biological processes and should lead to hypotheses that are testable in biological studies. It is expected that: (1) research collaborations will build on complementary investigator expertise in computation or modeling, theory, and/or experimental neuroscience; (2) the collaborations should involve a dynamic and possibly protracted period of development and refinement of models, theories, and/or analytical techniques, and intense interactions among scientists and engineers from different disciplines; and (3) the development and testing of new models or theories should provide a framework for the design of experiments and the generation of new hypotheses that can help reveal mechanisms and processes underlying normal or diseased states of the nervous system.

Sharing of Data, Software, and Other Resources: Sharing of data and software is highly recommended in all CRCNS projects, to facilitate the translation and dissemination of research results, to accelerate the development of generalizable approaches and tools that can be put to wide use by researchers, and to broaden the scope of collaboration in computational neuroscience and related communities.

Data Sharing Proposals may relate to any of the scientific topics that would be appropriate for Research Proposals under this solicitation. Data sharing projects should be specifically aimed at the preparation and deployment of data, software, code bases, stimuli, models, or other resources in a manner that is responsive to the needs of a broad community of researchers, for example, by providing a coherent collection of data and other resources covering a set of topics, systems, or methods of interest. The major innovation and intellectual merit of a data sharing proposal could be in the breadth, depth, or importance of the resources being shared. Technical innovation (e.g., to facilitate usability, access, and integration), and thoughtful approaches to community development and continuous improvement, are encouraged as needed to make the proposed resources maximally effective. CRCNS support for data sharing focuses primarily on data and other resources, not more general infrastructure, or research to acquire the data. Proposers of data sharing projects are strongly encouraged to build on existing facilities and services where possible, rather than develop infrastructure from scratch.

All CRCNS investigators are encouraged to coordinate with other data sharing projects and related activities, including national and international efforts to develop sustainable, extensible neuroscience resources. Further information about resources for data sharing is available on the CRCNS program web site (https://www.nsf.gov/crcns/).

Innovative educational and training opportunities are highly encouraged, to develop research capacity in computational neuroscience, to broaden participation in research and education, and to increase the impact of computational neuroscience research. Activities at all levels of educational and career development are welcome under this solicitation. International research experiences for students and early-career researchers are highly encouraged in all projects involving international collaborations.

A broad range of topics and approaches is welcome under this solicitation. The following list of examples illustrates some areas of research that are appropriate under this solicitation. This list is not intended to be exhaustive or exclusive.

• Explanatory, predictive and informative models and simulations of normal and abnormal structures and functions of the nervous system and related disorders;
• Mathematical, statistical and other quantitative analyses of research related to genetic, epigenetic, molecular, sub-cellular, cellular, network, systems, behavioral and/or cognitive neuroscience;
• Theoretical and computational approaches to delineate and understand the structures and functions of neural circuits;
• Theoretical and computational approaches that relate nervous system processes to learning algorithms, probabilistic representations, estimation, prediction, information theory, and inference;
• Data-driven and informatics-based approaches that exploit large-scale, high-throughput, heterogeneous and/or complex data;
• Theory and algorithms for designing experiments and integrating and analyzing data related to imaging and brain mapping technologies, including microscopic, macroscopic and multimodal methods;
• Methods for measuring and analyzing connectivity, dynamics, information, and causation in neural systems;
• Approaches exploiting new methods and tools for simulating complex multi-physics, multi-scale systems;
• Approaches that integrate neural and cognitive models;
• Data-intensive approaches to modeling and analysis;
• Efforts to compare large-scale experimental data to theoretical and computational models;
• Mathematical, statistical, and modeling approaches arising from areas such as communications, network science, the social, behavioral and economic sciences, engineering, and other fields;
• Multi-scale modeling spanning temporal scales, spatial scales, biological scales, and states (e.g., behavioral, normal and diseased states) to understand and predict processes, behaviors, and diseases;
• Theoretical and computational methods that can be applied to: common pathways, circuits, and mechanisms underlying multiple diseases in the nervous system; translational research including therapeutic devices and drug development; and/or clinical research and clinical trials (e.g., predictive models of diseases, adaptive design of clinical trials, and simulation of clinical trials);
• Theoretical and computational methods that can be applied across multiple areas of basic, translational, and clinical neuroscience research;
• Development and dissemination of analytical, numerical, or conceptual predictive models;
• Theoretical, computational, and/or analytical approaches to integrating brain measures across levels of analysis (e.g., molecules, cells and circuits); and
• Approaches to neuroscience problems that advance computational and engineering principles.

Examples of topics amenable to these approaches include but are not limited to the following:

• Neurodevelopment, neurodegeneration, neuroinflammation and repair;
• Pattern recognition and perception;
• Motor control mechanisms and sensorimotor integration;
• Learning, representation, and encoding;
• Cognitive and decision-making functions and dysfunction, including, e.g., impulse control and disinhibition;
• Neural origins of risk and time preference;
• Judgment, choice formation, and social-behavioral phenomena such as trust, competitiveness, and cooperation;
• Language and communication;
• Intellectual and developmental disabilities;
• Neural interface decoding and analysis, control, and modeling of processes affecting neural interfaces and neuroprostheses;
• Normal and abnormal sensory processing (vision, audition, olfaction, taste, balance, proprioception and somatic sensation);
• Neurological, neuromuscular and neurovascular disorders;
• Mental health, mental illness and related disorders;
• Alcohol and drug abuse related disorders, including, e.g., their interaction with eating disorders and other psychiatric and neurological disorders; and
• Emergent and state-space properties of dynamic neural networks and ensembles.

III. Award Information

As in previous years, there will be a minimum of $5 million available each year for this competition, with potentially $15 to $20 million annually, depending on the quality of proposals and availability of funds.

Award sizes for Research Projects (both domestic and international) are expected to range from approximately $100,000 to $250,000 per year in direct costs, with durations of three to five years. Many awards will be on the smaller end of this range. Proposers are strongly discouraged from requesting greater budgets than are necessary for the activities being proposed. Investigators contemplating four- or five-year projects are advised to discuss their project requirements with the appropriate agency contact(s) before submitting. The expected range of award sizes applies to the combined direct costs, expressed in US Dollars, of all components of a collaborative project for which funding is being sought from participating funders, including components inside and outside of the United States. The expected range of award sizes does not include the costs of foreign travel to international partnering institutions. International travel costs can be expected to vary depending on the countries and specific proposed activities, and could result in combined direct costs that exceed the expected range.

Awards for Data Sharing Projects will be scaled according to the needs of the project; typically they will be smaller in size than research awards. Investigators are encouraged to discuss their project requirements with the CRCNS Program Coordinator - NSF before submitting.

Estimated program budget, number of awards, and average award size and duration are subject to the availability of funds.

Upon conclusion of the review process, meritorious research proposals may be recommended for funding by one or more of the participating funding organizations, at the option of the funders, not the proposer. Subsequent grant administration procedures will be in accordance with the individual policies of the awarding agency.

Further information about agency processes and agency-specific award information is provided in Section VI.B. and Section VIII of this solicitation.

IV. Eligibility Information

Who May Submit Proposals:

The categories of proposers eligible to submit proposals to the National Science Foundation are identified in the NSF Proposal & Award Policies & Procedures Guide (PAPPG), Chapter I.E.

Who May Serve as PI:

There are no restrictions or limits.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or Co-PI: 2

In response to this solicitation, an investigator may participate as PI or Co-PI in no more than two proposals per review cycle. In the event that a PI or Co-PI does appear in either of these roles on more than two proposals, all proposals that include that person as a PI or Co-PI will be returned without review. This limit applies to all PIs and Co-PIs, based inside or outside of the United States.

Additional Eligibility Info:

• Proposal Limit: Proposals submitted in response to this solicitation may not duplicate or be substantially similar to other proposals concurrently under consideration by other programs or study sections of the participating agencies. Duplicate or substantially similar proposals will be returned without review.

V. Proposal Preparation And Submission Instructions

A. Proposal Preparation Instructions

Full Proposal Preparation Instructions: Proposers may opt to submit proposals in response to this Program Solicitation via Grants.gov or via the NSF FastLane system.

• Full proposals submitted via FastLane: Proposals submitted in response to this program solicitation should be prepared and submitted in accordance with the general guidelines contained in the NSF Grant Proposal Guide (GPG). The complete text of the GPG is available electronically on the NSF website at: https://www.nsf.gov/publications/pub_summ.jsp?ods_key=gpg. Paper copies of the GPG may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-7827 or by e-mail from nsfpubs@nsf.gov. Proposers are reminded to identify this program solicitation number in the program solicitation block on the NSF Cover Sheet For Proposal to the National Science Foundation. Compliance with this requirement is critical to determining the relevant proposal processing guidelines. Failure to submit this information may delay processing.

• Full proposals submitted via Grants.gov: Proposals submitted in response to this program solicitation via Grants.gov should be prepared and submitted in accordance with the NSF Grants.gov Application Guide: A Guide for the Preparation and Submission of NSF Applications via Grants.gov. The complete text of the NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: (https://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide). To obtain copies of the Application Guide and Application Forms Package, click on the Apply tab on the Grants.gov site, then click on the Apply Step 1: Download a Grant Application Package and Application Instructions link and enter the funding opportunity number, (the program solicitation number without the NSF prefix) and press the Download Package button. Paper copies of the Grants.gov Application Guide also may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-7827 or by e-mail from nsfpubs@nsf.gov.

In determining which method to utilize in the electronic preparation and submission of the proposal, please note the following:

Collaborative Proposals. All collaborative proposals submitted as separate submissions from multiple organizations must be submitted via the NSF FastLane system. Chapter II, Section D.3 of the Grant Proposal Guide provides additional information on collaborative proposals.

The following information supplements the Grant Proposal Guide or NSF Grants.gov Application Guide.

Proposals submitted in response to this solicitation should be prepared according to the general guidelines contained in the GPG, as modified by the following additional specific instructions for Research Proposals or Data Sharing Proposals. Additional instructions for International Proposals Seeking Parallel Funding apply only to proposals for projects involving collaborations among institutions in the United States and institutions in other countries, to be funded in parallel by participating agencies of the corresponding countries.Proposals involving other types of international collaboration may also be submitted, for consideration under standard US funding mechanisms. Proposers are advised to discuss such projects with the appropriate agency contact(s) before submitting. The instructions for specific classes of proposals are cumulative, as indicated in the table below:

If you are applying for the following class of proposal:	Refer to the following instructions:
	NSF Grant Proposal Guide and/or NSF Grants.gov Application Guide	CRCNS Proposal Preparation Instructions (Section V.A.) for...			CRCNS Agency-Specific Information (Section VIII) for...
		Research Proposals	Data Sharing Proposals	International Proposals Seeking Parallel Funding	NIH, NSF	ANR, BMBF, BSF
US Research Proposal	X	X			X
US Data Sharing Proposal	X		X		X
US-Germany, US-France, US-Israel, or Multilateral Research Proposal	X	X		X	X	X
US-Germany, US-France, US-Israel, or Multilateral Data Sharing Proposal	X		X	X	X	X

Research Proposals

The following additional instructions apply to all Research Proposals submitted in response to this solicitation. If the proposal seeks parallel funding for an international collaboration, please also refer to the instructions below for International Proposals Seeking Parallel Funding.

1. Cover Sheet: Titles for research proposals should begin with the phrase, "CRCNS Research Proposal:" Additional title prefixes (e.g., "Collaborative Research:" or "RUI:") may be included, as applicable, in any order. Although all CRCNS Research Proposals must describe scientific collaborations, they do not need to be collaborative proposals in the administrative sense (GPG Chapter II.D.5). The collaborative status on the cover sheet indicates whether two or more organizations are seeking U.S. funding, not the collaborative nature of the research.
2. Project Summary: For projects with medical relevance, the statement on broader impacts should include a summary of the project's potential contributions to understanding, preventing, and managing disease, and enhancing public health.
3. Project Description: Proposals for research projects must include a Coordination Plan. Up to two additional pages are permitted in the Project Description for this purpose only, allowing a maximum of 17 pages total. If the Project Description, excluding the Coordination Plan, exceeds 15 pages, the proposal will be returned without review. The Coordination Plan must include: 1) the specific roles of the collaborating PIs, Co-PIs, other Senior Personnel and paid consultants at all organizations involved; 2) how the project will be managed across institutions and disciplines; 3) identification of the specific coordination mechanisms that will enable cross-institution and/or cross-discipline scientific integration (e.g., workshops, graduate student exchange, project meetings at conferences, use of videoconferencing and other communication tools, software repositories, etc.), and 4) specific references to the budget line items that support these coordination mechanisms. The Project Description must include results from prior NSF and/or CRCNS support if any PI or co-PI identified on the project has received NSF funding, or CRCNS funding from another participating agency, in the past five years. Sharing of data, software, and/or other resources under prior support must be addressed. The full requirements for Results from Prior Support are listed in GPG Chapter II.C.2.d.(iii).
4. Supplementary Documents: Supplementary documents are limited to the specific types of documentation listed in the GPG (Chapter II.C.2.j), with the following exceptions:

Human Subjects Protection. Proposals involving human subjects should include a supplementary document, no more than two pages in length, summarizing potential risks to human subjects; plans for recruitment and informed consent; inclusion of women, minorities, and children; and planned procedures to protect against or minimize potential risks. Only one Human Subjects Protection document, covering all collaborative components of the project within the two-page limit, may be submitted per project.

Vertebrate Animals. Proposals involving vertebrate animals should include a supplementary document, no more than two pages in length, that addresses the following points:

• Detailed description of the proposed use of the animals, including species, strains, ages, sex, and number to be used;
• Justification for the use of animals, choice of species, and numbers to be used;
• Description of procedures for minimizing discomfort, distress, pain, and injury; and
• Method of euthanasia and the reasons for its selection.

Only one Vertebrate Animals document, covering all collaborative components of the project within the two-page limit, may be submitted per project.

Data Management Plan. All proposals must include a supplementary document on data management as specified in the GPG (Chapter II.C.2.j) and CISE Guidance for Data Management Plans (https://www.nsf.gov/cise/cise_dmp.jsp). As needed, the Data Management Plan should also address possible differences between U.S. and applicable non-U.S. data protection requirements. Only one Data Management Plan, covering all collaborative components of the project within the two-page limit, may be submitted per project.

Letters of Collaboration. These should be limited to stating the intent to collaborate and should not contain endorsements or evaluation of the proposed project. The recommended format for letters of collaboration is as follows:

"If the proposal submitted by Dr. [insert the full name of the Principal Investigator] entitled [insert the proposal title] is selected for funding, it is my intent to collaborate and/or commit resources as detailed in the Project Description or the Facilities, Equipment or Other Resources section of the proposal."

Proposals containing special information or supplementary documentation that has not been explicitly allowed in the GPG or this solicitation, such as article reprints or preprints, or appendices, will be returned without review.

Data Sharing Proposals

The following additional instructions apply to all Data Sharing Proposals submitted in response to this solicitation. If the proposal seeks parallel funding for an international collaboration, please also refer to the further instructions below for International Proposals Seeking Parallel Funding.

1. Cover Sheet: Titles for data sharing proposals should begin with the phrase, "CRCNS Data Sharing Proposal:"
2. Project Summary: As with the Research Proposals, the statement on broader impacts should address medical relevance if appropriate.
3. Project Description: Project descriptions for data sharing proposals should address the following points:

• Description and significance of the data, software, code bases, stimuli, models, or other resources, including their quality, scientific importance, structure, format, and scale;
• Relationship to similar data or other resources, relevant standards, coordination with relevant related activities and infrastructure, and potential for integration with other resources;
• Anticipated range of uses for research and education in computational neuroscience or other fields;
• Plan for preparation and deployment, including technical plans, metadata and documentation, and plans for outreach and community input; and
• Anticipated implementation timetable and strategy for evaluation and management over the course of the award period.

For proposals involving multiple collaborators, institutions, or collaborating contributors, a Coordination Plan, as described above under Research Proposals, is allowed but not required. As with the Research Proposals, up to two additional pages are permitted in the Project Description for the Coordination Plan, for a maximum of 17 pages total, and results from prior NSF and/or CRCNS support -- including sharing of data, software, and/or other resources under prior support -- must be included if any PI or Co-PI identified on the project has received NSF or CRCNS funding in the past five years.

4. Supplementary Documents: Data management issues are integral to data sharing projects and should be addressed within the project description; however, a Data Management Plan is also required as a supplementary document. Please include a supplementary document on data management that refers the reader to the project description. Proposals should include a supplementary document on Human Subjects Protection, as described above, if sharing of the data or other resources raises potential human subjects issues (e.g., confidentiality). Letters of Collaboration should be limited to the one-sentence format recommended above. Other supplementary documents, as described above for Research Proposals, may be included as applicable.

Proposals containing special information or supplementary documentation that has not been explicitly allowed in the GPG or this solicitation, such as article reprints or preprints, or appendices, will be returned without review.

International Proposals Seeking Parallel Funding

The following special instructions apply to proposals for projects involving bilateral or multilateral collaborations among institutions in the United States and institutions in other countries, to be funded in parallel by participating agencies of the corresponding countries. US investigators should prepare a proposal according to the instructions below; collaborating investigators from other countries should refer to instructions from the appropriate partner agency, referenced in Section VIII of this solicitation.

1. A proposal to NSF should be prepared according to the guidelines above for Research Proposals or Data Sharing Proposals, as appropriate. Proposal titles should begin with a phrase describing the countries involved and the type of proposal, such as "CRCNS US-German Research Proposal:" A full list of countries and proposal types that will be considered for parallel funding can be found in Section VIII of this solicitation. The NSF proposal should be submitted by the US partner in the collaboration. The NSF proposal should describe the full international collaborative project as a unified entity.
2. The collaborating PIs, Co-PIs, and senior personnel, from all participating countries, must be listed in full at the top of the first page of the Project Description, along with their departmental and institutional affiliations. The NSF cover sheet and biographical sketches will include only the investigators affiliated with US institutions. Biographical sketches for PIs, Co-PIs, and senior personnel from outside of the United States must be included as supplementary documents in the NSF proposal.
3. All International Proposals Seeking Parallel Funding must include a Coordination Plan, which should include specific plans for exchange of students and researchers, including timing, duration, and logistical arrangements for visits, and roles of specific project personnel. NSF specifically encourages US students and early-career researchers to spend substantive time abroad collaborating with researchers in foreign institutions. (As with the domestic proposals, up to two additional pages are permitted in the Project Description for the Coordination Plan, for a maximum of 17 pages total.)
4. The NSF budget pages (in US Dollars) should not include any of the costs of components of the project outside of the United States that are to be funded by partner agencies. Budgets for these components of the project (in the currencies used by the partner agencies) must be prepared according to the instructions of partner agencies, referenced in Section VIII of this solicitation, and included as a supplementary document in the NSF proposal. Expected award sizes described in Section III of this solicitation apply to the combined budgets of all components of the project (expressed in US Dollars), including components inside and outside of the United States, but not including the costs of foreign travel to international partnering institutions.
5. Statements of current and pending support for investigators outside of the United States; and statements of their facilities, equipment, and other resources; should be submitted as supplementary documents in the NSF proposal.
6. Supplementary documents pursuant to Data Management Plans and, as needed, Postdoctoral Mentoring Plans, Human Subjects Protection, and Vertebrate Animals, should cover all components of the collaborative project, inside and outside of the United States. No more than one document of each of these types may be submitted per collaborative project. Page limits for these documents are specified above and in the GPG.
7. Collaborating PIs from outside of the United States are referred to Section VIII of this solicitation for further instructions about applying to the appropriate partner funding agency.

B. Budgetary Information

Cost Sharing:

Cost sharing is not required under this solicitation.

Indirect Cost (F&A) Limitations:

Foreign organizations that do not have a current U.S. federally negotiated indirect cost rate(s) are limited to a de minimis indirect cost rate recovery of 10% of modified total direct costs. Foreign grantees that have a U.S. federally negotiated indirect cost rate(s) may recover indirect costs at the current negotiated rate.

Other Budgetary Limitations:

Budgets should include travel funds for the PI to attend an annual CRCNS Principal Investigators' meeting.

C. Due Dates

• Full Proposal Deadline(s) (due by 5 p.m. submitter's local time):

       December 19, 2016

D. FastLane/Grants.gov Requirements

For Proposals Submitted Via FastLane:

To prepare and submit a proposal via FastLane, see detailed technical instructions available at: https://www.fastlane.nsf.gov/a1/newstan.htm. For FastLane user support, call the FastLane Help Desk at 1-800-673-6188 or e-mail fastlane@nsf.gov. The FastLane Help Desk answers general technical questions related to the use of the FastLane system. Specific questions related to this program solicitation should be referred to the NSF program staff contact(s) listed in Section VIII of this funding opportunity.

For Proposals Submitted Via Grants.gov:

Before using Grants.gov for the first time, each organization must register to create an institutional profile. Once registered, the applicant's organization can then apply for any federal grant on the Grants.gov website. Comprehensive information about using Grants.gov is available on the Grants.gov Applicant Resources webpage: http://www.grants.gov/web/grants/applicants.html. In addition, the NSF Grants.gov Application Guide (see link in Section V.A) provides instructions regarding the technical preparation of proposals via Grants.gov. For Grants.gov user support, contact the Grants.gov Contact Center at 1-800-518-4726 or by email: support@grants.gov. The Grants.gov Contact Center answers general technical questions related to the use of Grants.gov. Specific questions related to this program solicitation should be referred to the NSF program staff contact(s) listed in Section VIII of this solicitation.

Submitting the Proposal: Once all documents have been completed, the Authorized Organizational Representative (AOR) must submit the application to Grants.gov and verify the desired funding opportunity and agency to which the application is submitted. The AOR must then sign and submit the application to Grants.gov. The completed application will be transferred to the NSF FastLane system for further processing.

Proposers that submitted via FastLane are strongly encouraged to use FastLane to verify the status of their submission to NSF. For proposers that submitted via Grants.gov, until an application has been received and validated by NSF, the Authorized Organizational Representative may check the status of an application on Grants.gov. After proposers have received an e-mail notification from NSF, Research.gov should be used to check the status of an application.

VI. Proposal Processing And Review Procedures

NSF will coordinate and manage the review of proposals jointly with participating domestic and foreign funding organizations, through a joint panel review process used by all participating funders. Relevant information about proposals and reviews of proposals will be shared between the participating organizations as appropriate. Further information on the processes and requirements of participating funding organizations is detailed in this Section and in Section VIII of this solicitation.

Proposals received by NSF are assigned to the appropriate NSF program for acknowledgement and, if they meet NSF requirements, for review. All proposals are carefully reviewed by a scientist, engineer, or educator serving as an NSF Program Officer, and usually by three to ten other persons outside NSF either as ad hoc reviewers, panelists, or both, who are experts in the particular fields represented by the proposal. These reviewers are selected by Program Officers charged with oversight of the review process. Proposers are invited to suggest names of persons they believe are especially well qualified to review the proposal and/or persons they would prefer not review the proposal. These suggestions may serve as one source in the reviewer selection process at the Program Officer's discretion. Submission of such names, however, is optional. Care is taken to ensure that reviewers have no conflicts of interest with the proposal. In addition, Program Officers may obtain comments from site visits before recommending final action on proposals. Senior NSF staff further review recommendations for awards. A flowchart that depicts the entire NSF proposal and award process (and associated timeline) is included in the GPG as Exhibit III-1.

A comprehensive description of the Foundation's merit review process is available on the NSF website at: http://nsf.gov/bfa/dias/policy/merit_review/.

Proposers should also be aware of core strategies that are essential to the fulfillment of NSF's mission, as articulated in Empowering the Nation Through Discovery and Innovation: NSF Strategic Plan for Fiscal Years (FY) 2011-2016. These strategies are integrated in the program planning and implementation process, of which proposal review is one part. NSF's mission is particularly well-implemented through the integration of research and education and broadening participation in NSF programs, projects, and activities.

One of the core strategies in support of NSF's mission is to foster integration of research and education through the programs, projects and activities it supports at academic and research institutions. These institutions provide abundant opportunities where individuals may concurrently assume responsibilities as researchers, educators, and students, and where all can engage in joint efforts that infuse education with the excitement of discovery and enrich research through the variety of learning perspectives.

Another core strategy in support of NSF's mission is broadening opportunities and expanding participation of groups, institutions, and geographic regions that are underrepresented in STEM disciplines, which is essential to the health and vitality of science and engineering. NSF is committed to this principle of diversity and deems it central to the programs, projects, and activities it considers and supports.

A. Merit Review Principles and Criteria

The National Science Foundation strives to invest in a robust and diverse portfolio of projects that creates new knowledge and enables breakthroughs in understanding across all areas of science and engineering research and education. To identify which projects to support, NSF relies on a merit review process that incorporates consideration of both the technical aspects of a proposed project and its potential to contribute more broadly to advancing NSF's mission "to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense; and for other purposes." NSF makes every effort to conduct a fair, competitive, transparent merit review process for the selection of projects.

1. Merit Review Principles

These principles are to be given due diligence by PIs and organizations when preparing proposals and managing projects, by reviewers when reading and evaluating proposals, and by NSF program staff when determining whether or not to recommend proposals for funding and while overseeing awards. Given that NSF is the primary federal agency charged with nurturing and supporting excellence in basic research and education, the following three principles apply:

• All NSF projects should be of the highest quality and have the potential to advance, if not transform, the frontiers of knowledge.
  
• NSF projects, in the aggregate, should contribute more broadly to achieving societal goals. These "Broader Impacts" may be accomplished through the research itself, through activities that are directly related to specific research projects, or through activities that are supported by, but are complementary to, the project. The project activities may be based on previously established and/or innovative methods and approaches, but in either case must be well justified.
  
• Meaningful assessment and evaluation of NSF funded projects should be based on appropriate metrics, keeping in mind the likely correlation between the effect of broader impacts and the resources provided to implement projects. If the size of the activity is limited, evaluation of that activity in isolation is not likely to be meaningful. Thus, assessing the effectiveness of these activities may best be done at a higher, more aggregated, level than the individual project.

With respect to the third principle, even if assessment of Broader Impacts outcomes for particular projects is done at an aggregated level, PIs are expected to be accountable for carrying out the activities described in the funded project. Thus, individual projects should include clearly stated goals, specific descriptions of the activities that the PI intends to do, and a plan in place to document the outputs of those activities.

These three merit review principles provide the basis for the merit review criteria, as well as a context within which the users of the criteria can better understand their intent.

2. Merit Review Criteria

All NSF proposals are evaluated through use of the two National Science Board approved merit review criteria. In some instances, however, NSF will employ additional criteria as required to highlight the specific objectives of certain programs and activities.

The two merit review criteria are listed below. Both criteria are to be given full consideration during the review and decision-making processes; each criterion is necessary but neither, by itself, is sufficient. Therefore, proposers must fully address both criteria. (GPG Chapter II.C.2.d.i. contains additional information for use by proposers in development of the Project Description section of the proposal.) Reviewers are strongly encouraged to review the criteria, including GPG Chapter II.C.2.d.i., prior to the review of a proposal.

When evaluating NSF proposals, reviewers will be asked to consider what the proposers want to do, why they want to do it, how they plan to do it, how they will know if they succeed, and what benefits could accrue if the project is successful. These issues apply both to the technical aspects of the proposal and the way in which the project may make broader contributions. To that end, reviewers will be asked to evaluate all proposals against two criteria:

• Intellectual Merit: The Intellectual Merit criterion encompasses the potential to advance knowledge; and
  
• Broader Impacts: The Broader Impacts criterion encompasses the potential to benefit society and contribute to the achievement of specific, desired societal outcomes.

The following elements should be considered in the review for both criteria:

1. What is the potential for the proposed activity to
   1. Advance knowledge and understanding within its own field or across different fields (Intellectual Merit); and
   2. Benefit society or advance desired societal outcomes (Broader Impacts)?
2. To what extent do the proposed activities suggest and explore creative, original, or potentially transformative concepts?
3. Is the plan for carrying out the proposed activities well-reasoned, well-organized, and based on a sound rationale? Does the plan incorporate a mechanism to assess success?
4. How well qualified is the individual, team, or organization to conduct the proposed activities?
5. Are there adequate resources available to the PI (either at the home organization or through collaborations) to carry out the proposed activities?

Broader impacts may be accomplished through the research itself, through the activities that are directly related to specific research projects, or through activities that are supported by, but are complementary to, the project. NSF values the advancement of scientific knowledge and activities that contribute to achievement of societally relevant outcomes. Such outcomes include, but are not limited to: full participation of women, persons with disabilities, and underrepresented minorities in science, technology, engineering, and mathematics (STEM); improved STEM education and educator development at any level; increased public scientific literacy and public engagement with science and technology; improved well-being of individuals in society; development of a diverse, globally competitive STEM workforce; increased partnerships between academia, industry, and others; improved national security; increased economic competitiveness of the United States; and enhanced infrastructure for research and education.

Proposers are reminded that reviewers will also be asked to review the Data Management Plan and the Postdoctoral Researcher Mentoring Plan, as appropriate.

Additional Solicitation Specific Review Criteria

For this solicitation, clinical and technological applications are specifically included among the societally relevant outcomes that could be related to a project's broader impacts, in addition to the potential outcomes listed above.

The following additional review criterion reflects this solicitation's central goal of enabling high-quality collaborative research. Following are suggested considerations pertaining to the quality and value of collaboration, not all of which will necessarily apply to any given proposal:

Quality and value of collaboration
Is the expertise of the proposers complementary and well-suited to the problems being addressed? Does the collaboration productively bring together new combinations of investigators, approaches, or resources? Are the specific roles of each collaborating investigator clear? Is the collaborative activity coordinated efficiently and effectively? To what extent will it contribute to the advancement of multiple collaborating disciplines? To what extent will it lead to the development of high-quality resources that will be useful to the research community at large? To what extent will it provide unique collaborative research experiences for participating students and early-career researchers?

For proposals involving international collaborations, reviewers will consider: mutual benefits, true intellectual collaboration with the foreign partner(s), benefits to be realized from the expertise and specialized skills, facilities, sites and/or resources of the international counterpart, and active research engagement of U.S. students and early-career researchers, where such individuals are engaged in the research.

NIH Review Criteria

The mission of the NIH is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life and reduce illness and disability. In their evaluations of Intellectual Merit, reviewers will be asked to consider the following criteria that are used by NIH:

Overall Impact. Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following five core review criteria, and additional review criteria (as applicable for the project proposed).

Significance. Does the project address an important problem or a critical barrier to progress in the field? Is there a strong scientific premise for the project? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?

Investigator(s). Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

Innovation. Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?

Approach. Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Have the investigators presented strategies to ensure a robust and unbiased approach, as appropriate for the work proposed? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? Have the investigators presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects?

If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?

Environment. Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?

Where applicable, the following items will also be considered:

Protections for Human Subjects. For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.

For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials.

Inclusion of Women, Minorities, and Children. When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is justified in terms of the scientific goals and research strategy proposed.

Vertebrate Animals. The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following criteria: (1) description of procedures involving animals including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. For additional information, see http://grants.nih.gov/grants/olaw/VASchecklist.pdf.

Biohazards. Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

Budget and Period of Support. Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

B. Review and Selection Process

Proposals submitted in response to this program solicitation will be reviewed by Ad hoc Review and/or Panel Review.

Reviewers will be asked to evaluate proposals using two National Science Board approved merit review criteria and, if applicable, additional program specific criteria. A summary rating and accompanying narrative will generally be completed and submitted by each reviewer and/or panel. The Program Officer assigned to manage the proposal's review will consider the advice of reviewers and will formulate a recommendation.

NSF Process: Those proposals selected for funding by NSF will be handled in accordance with standard NSF procedures. After scientific, technical and programmatic review and consideration of appropriate factors, the NSF Program Officer recommends to the cognizant Division Director whether the proposal should be declined or recommended for award. NSF is striving to be able to tell applicants whether their proposals have been declined or recommended for funding within six months. The time interval begins on the date of receipt. The interval ends when the Division Director accepts the Program Officer's recommendation.

A summary rating and accompanying narrative will be completed and submitted by each reviewer. In all cases, reviews are treated as confidential documents. Verbatim copies of reviews, excluding the names of the reviewers, are sent to the Principal Investigator/Project Director by the Program Officer. In addition, the proposer will receive an explanation of the decision to award or decline funding.

In all cases, after programmatic approval has been obtained, the proposals recommended for funding will be forwarded to the Division of Grants and Agreements for review of business, financial, and policy implications and the processing and issuance of a grant or other agreement. Proposers are cautioned that only a Grants and Agreements Officer may make commitments, obligations or awards on behalf of NSF or authorize the expenditure of funds. No commitment on the part of NSF should be inferred from technical or budgetary discussions with a NSF Program Officer. A Principal Investigator or organization that makes financial or personnel commitments in the absence of a grant or cooperative agreement signed by the NSF Grants and Agreements Officer does so at their own risk.

NIH Process: For those proposals that are selected for potential funding by participating NIH Institutes or Centers, the PI will be required to resubmit the proposal in an NIH-approved format directly to the Center for Scientific Review (http://www.csr.nih.gov/) of the NIH. PIs invited to resubmit to NIH will receive further information on resubmission procedures from NIH. An applicant will not be allowed to increase the proposed budget or change the scientific content of the application in the resubmission to the NIH. NIH budgets may not exceed $250,000 in direct costs, and the total direct costs requested for the all years may not exceed the total requested on the NSF application. However, in some cases, NIH Institutes may request that the budget request be reallocated across the years of the grant to conform to NIH modular budget practices. Indirect costs on any foreign subawards/subcontracts will be limited to eight (8) percent. Applicants will be expected to utilize the Multiple Principal Investigator option at the NIH (http://grants.nih.gov/grants/multi_PI/) as appropriate. These NIH applications will be entered into the NIH IMPAC II system. The results of the review will be presented to the involved Institutes' or Centers' National Advisory Councils for the second level of review. Subsequent to the Council reviews, NIH Institutes and Centers will make their funding determinations and selected awards will be made. Subsequent grant administration procedures for NIH awardees, including those related to New and Early Stage Investigators (http://grants.nih.gov/grants/new_investigators/), will be in accordance with the policies of NIH. Applications selected for NIH funding will use the NIH R01 funding mechanism.

At the end of the project period, renewal applications for projects funded by the NIH are expected to be submitted directly to the NIH as Renewal Applications, rather than as proposals to the CRCNS program. Principal Investigators should contact their NIH Program Officer for additional information. For informational purposes, NIH Principal Investigators may wish to consult the NIAID web site, "All About Grants," which provides excellent generic information about all aspects of NIH grantsmanship, including Renewal Applications (http://www.niaid.nih.gov/researchfunding/grant/pages/aag.aspx).

BMBF Process: On the basis of the evaluation, suitable project ideas will be selected for funding. The applicants will be informed in writing of the result of the selection procedure.

In the second phase of the procedure, applicants whose applications have received a positive evaluation will be invited to present a formal application for funding. A decision will be made after a final evaluation. Forms for funding applications, guidelines, leaflets, information and auxiliary terms and conditions are available on the Internet at http://www.foerderportal.bund.de/ or can be obtained from the project management organization. Applicants are strongly advised to use the electronic application system "easy" to draft (project outlines and) formal applications (http://www.foerderportal.bund.de/).

ANR Process: Taking into consideration the joint panel review recommendation outcome and consultation with the participating funding organizations, ANR will select the projects to be funded. ANR will inform the French applicants of the outcome of the selection. After programmatic approval, the grant agreements of the selected projects will be issued in accordance with ANR standard funding regulations.

BSF Process: BSF requires parallel submission of the proposal by the U.S. and Israeli PIs, according to its submission regulations and using an identical project description to that submitted to the NSF. However, BSF will not conduct an independent selection process, but rather will review the research programs selected for funding by the NSF and/or NIH and include Israeli PIs, and in most cases fund them if sufficient resources are available. BSF will notify all applicants of the results and online availability of the review material. BSF submission instructions can be found using the link: http://www.bsf.org.il/ElectronicSubmission/GatewayFormsAndGuidelines.aspx?PageId=7&innerTextID=0

VII. NSF Award Administration Information

A. Notification of the Award

Notification of an NSF award is made to the submitting organization by a Grants Officer in the Division of Grants and Agreements. Organizations whose proposals are declined will be advised as promptly as possible by the cognizant NSF Program administering the program. Verbatim copies of reviews, not including the identity of the reviewer, will be provided automatically to the Principal Investigator. (See Section VI.B. for additional information on the review process).

B. Award Conditions

An NSF award consists of: (1) the award notice, which includes any special provisions applicable to the award and any numbered amendments thereto; (2) the budget, which indicates the amounts, by categories of expense, on which NSF has based its support (or otherwise communicates any specific approvals or disapprovals of proposed expenditures); (3) the proposal referenced in the award notice; (4) the applicable award conditions, such as Grant General Conditions (GC-1)*; or Research Terms and Conditions* and (5) any announcement or other NSF issuance that may be incorporated by reference in the award notice. Cooperative agreements also are administered in accordance with NSF Cooperative Agreement Financial and Administrative Terms and Conditions (CA-FATC) and the applicable Programmatic Terms and Conditions. NSF awards are electronically signed by an NSF Grants and Agreements Officer and transmitted electronically to the organization via e-mail.

*These documents may be accessed electronically on NSF's Website at https://www.nsf.gov/awards/managing/award_conditions.jsp?org=NSF. Paper copies may be obtained from the NSF Publications Clearinghouse, telephone (703) 292-7827 or by e-mail from nsfpubs@nsf.gov.

More comprehensive information on NSF Award Conditions and other important information on the administration of NSF awards is contained in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) Chapter VII, available electronically on the NSF Website at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=papp.

Special Award Conditions:

Attribution of support in publications must acknowledge the joint program, as well as the funding organization and award number, by including a phrase such as, "as part of the NSF/NIH/ANR/BMBF/BSF Collaborative Research in Computational Neuroscience Program."

C. Reporting Requirements

For all multi-year grants awarded by NSF (including both standard and continuing grants), the Principal Investigator must submit an annual project report to the cognizant Program Officer at least 90 days before the end of the current budget period. (Some programs or awards require more frequent project reports). Within 90 days after expiration of a grant, the PI also is required to submit a final project report.

Failure to provide the required annual or final project reports will delay NSF review and processing of any future funding increments as well as any pending proposals for that PI. PIs should examine the formats of the required reports in advance to assure availability of required data.

PIs are required to use NSF's electronic project-reporting system, available through FastLane, for preparation and submission of annual and final project reports. Such reports provide information on activities and findings, project participants (individual and organizational) publications; and, other specific products and contributions. PIs will not be required to re-enter information previously provided, either with a proposal or in earlier updates using the electronic system. Submission of the report via FastLane constitutes certification by the PI that the contents of the report are accurate and complete.

VIII. Agency Contacts And Agency-specific Information

Please note that the program contact information is current at the time of publishing. See program website for any updates to the points of contact.

General inquiries regarding this program should be made to:

• Jasmine Owens, CRCNS Administrative Coordinator - NSF; Program Analyst, Division of Information and Intelligent Systems, National Science Foundation, 1125 S, telephone: (703) 292-8377, fax: (703) 292-9073, email: jowens@nsf.gov

• Kenneth Whang, CRCNS Program Coordinator - NSF; Program Director, Division of Information and Intelligent Systems, National Science Foundation, 1125 S, telephone: (703) 292-5149, fax: (703) 292-9073, email: kwhang@nsf.gov

For questions related to the use of FastLane, contact:

• FastLane Help Desk, telephone: 1-800-673-6188; e-mail: fastlane@nsf.gov.

For questions relating to Grants.gov contact:

• Grants.gov Contact Center: If the Authorized Organizational Representatives (AOR) has not received a confirmation message from Grants.gov within 48 hours of submission of application, please contact via telephone: 1-800-518-4726; e-mail: support@grants.gov.

Questions concerning a particular project’s focus, direction and relevance to a participating funding organization should be addressed to:

ANR

The French National Research Agency (ANR) will consider US-French Research Proposals and US-French Data Sharing Proposals, Multilateral Research Proposals, and Multilateral Data Sharing Proposals submitted to NSF in response to this solicitation. The modalities of participation of the French applicants are presented in the annex to this solicitation available on the ANR website at http://www.anr.fr/crcns-2017. It is not necessary to submit a parallel proposal directly to ANR; nonetheless, a notification of submission should be sent to mathieu.girerd@anr.fr and sheyla.mejia@anr.fr no later than December 23, 2016.

The French applicants are strongly encouraged to contact ANR prior to submission:

Mathieu Girerd, Scientific Officer, Information and Communication Sciences and Technologies Department, telephone: +33 1 7354 8213, email: mathieu.girerd@anr.fr

Sheyla Mejia, Scientific Officer, Biology and Health Department, telephone: +33 1 7809 8014, email: sheyla.mejia@anr.fr

BMBF

Germany's Federal Ministry of Education and Research will consider US-German Research Proposals, US-German Data Sharing Proposals, Multilateral Research Proposals, and Multilateral Data Sharing Proposals submitted in response to this solicitation. The durations of these projects are expected to be no greater than three years. Investigators contemplating projects that would require longer durations are advised to discuss their project requirements with the appropriate agency contact(s) before submitting. Collaborating investigators in projects selected for funding that involve Germany will provide assurance to BMBF that a cooperation agreement, covering issues including intellectual property, has been established. A proposal with the same project description as the proposal to NSF must be submitted by the German PI to BMBF. German applicants are referred to the BMBF Richtlinien (http://www.gesundheitsforschung-bmbf.de/de/6662.php) for further instructions, and are urged to contact the project management organization for advice on applications:

Rainer Girgenrath, DLR Projektträger für das BMBF, telephone: +49 228 3821 1200, email: rainer.girgenrath@dlr.de, web: http://www.dlr.de/pt

BSF

The U.S.-Israel Binational Science Foundation will consider US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, Multilateral Research Proposals, and Multilateral Data Sharing Proposals submitted in response to this solicitation. No more than five years of support may be requested. A proposal with the same project description as the proposal to NSF must be submitted by the Israeli PI to the BSF. The budget for the Israeli component of the project should be expressed in US Dollars. Submittal instructions are available at: http://www.bsf.org.il/ElectronicSubmission/GatewayFormsAndGuidelines.aspx?PageId=7&innerTextID=0

Questions should be directed to:

Yael Dressler, telephone: +972-2-5828239, email: yael@bsf.org.il

Rachel Haring, telephone: +972-2-5828239, email: heni@bsf.org.il

NIH

CRCNS is affiliated with the NIH Blueprint for Neuroscience Research (http://neuroscienceblueprint.nih.gov/), and involves nine participating NIH Institutes and Centers. An NIH Notice (http://grants.nih.gov/grants/guide/notice-files/NOT-MH-14-002.html) is being issued in parallel with this solicitation. Proposals are selected for potential NIH funding on the basis of the common CRCNS joint review process; resubmission of proposals directly to NIH is by invitation only. No NIH awards will exceed $250,000 per year in direct costs. Further questions may be directed to:

Theresa H. Cruz, Program Officer, Eunice Kennedy Shriver National Institute of Child Health and Human Development, telephone: (301) 496-9233, email: cruzth@mail.nih.gov

James Gnadt, Program Director, Systems & Cognitive Neuroscience, National Institute of Neurological Disorders and Stroke, telephone: (301) 496-9964, email: gnadtjw@ninds.nih.gov

John A. Matochik, Program Director, Division of Neuroscience and Behavior, National Institute on Alcoholism and Alcohol Abuse, telephone: (301) 451-7319, email: jmatochi@mail.nih.gov

Grace C. Y. Peng, Program Director, Discovery Science and Technology, National Institute of Biomedical Imaging and Bioengineering, telephone: (301) 451-4778, email: penggr@mail.nih.gov

Christopher Platt, Program Director, Central Pathways for Hearing and Balance, National Institute on Deafness and Other Communication Disorders, telephone: (301) 496-1804, email: plattc@nidcd.nih.gov

Michele Ferrante, Program Chief, Theoretical and Computational Neuroscience Program, National Institute of Mental Health, telephone: (301) 435-6782, email: michele.ferrante@nih.gov

Wen Chen, Program Director, National Center for Complementary and Integrative Health, telephone: (301) 451-3989, email: chenw@mail.nih.gov

Susan Volman, Program Director, Division of Neuroscience and Behavioral Research, National Institute on Drug Abuse, telephone: (301) 435-1315, email: svolman@nida.nih.gov

Cheri Wiggs, Program Director, Division of Extramural Research, National Eye Institute, telephone: (301) 451-2020, email: wiggsc@nei.nih.gov

NSF

Further questions for NSF program officers may be directed to:

Kenneth Whang, Program Director, Division of Information and Intelligent Systems, 1125S, telephone: (703) 292-5149, fax: (703) 292-9073, email: kwhang@nsf.gov

Michele Grimm, Program Director, Division of Chemical, Bioengineering, Environmental, and Transport Systems, 565S, telephone: (703) 292-4641, email: mgrimm@nsf.gov

Mary Ann Horn, Program Director, Division of Mathematical Sciences, 1025N, telephone: (703) 292-4879, email: mhorn@nsf.gov

Alumit Ishai, Program Director, Division of Behavioral and Cognitive Sciences, 995N, telephone: (703) 292-5145, email: aishai@nsf.gov

Maija Kukla, Program Director, Office of International Science and Engineering, II-1155, telephone: (703) 292-4940, email: mkukla@nsf.gov

Jonathan Leland, Program Director, Division of Social and Economic Sciences, 995N, telephone: (703) 292-7285, email: jleland@nsf.gov

William L. Miller, Science Advisor, Division of Advanced Cyberinfrastructure, 1145S, telephone: (703) 292-7886, email: wlmiller@nsf.gov

Rosemary Renaut, Program Director, Division of Mathematical Sciences, 1025N, telephone: (703) 292-2112, email: rrenaut@nsf.gov

Floh Thiels, Program Director, Division of Integrative and Organismal Systems, 685S, telephone: (703) 292-8167, email: ethiels@nsf.gov

IX. Other Information

The NSF website provides the most comprehensive source of information on NSF Directorates (including contact information), programs and funding opportunities. Use of this website by potential proposers is strongly encouraged. In addition, "NSF Update" is an information-delivery system designed to keep potential proposers and other interested parties apprised of new NSF funding opportunities and publications, important changes in proposal and award policies and procedures, and upcoming NSF Grants Conferences. Subscribers are informed through e-mail or the user's Web browser each time new publications are issued that match their identified interests. "NSF Update" also is available on NSF's website.

Grants.gov provides an additional electronic capability to search for Federal government-wide grant opportunities. NSF funding opportunities may be accessed via this mechanism. Further information on Grants.gov may be obtained at http://www.grants.gov.

About The National Science Foundation

The National Science Foundation (NSF) is an independent Federal agency created by the National Science Foundation Act of 1950, as amended (42 USC 1861-75). The Act states the purpose of the NSF is "to promote the progress of science; [and] to advance the national health, prosperity, and welfare by supporting research and education in all fields of science and engineering."

NSF funds research and education in most fields of science and engineering. It does this through grants and cooperative agreements to more than 2,000 colleges, universities, K-12 school systems, businesses, informal science organizations and other research organizations throughout the US. The Foundation accounts for about one-fourth of Federal support to academic institutions for basic research.

NSF receives approximately 40,000 proposals each year for research, education and training projects, of which approximately 11,000 are funded. In addition, the Foundation receives several thousand applications for graduate and postdoctoral fellowships. The agency operates no laboratories itself but does support National Research Centers, user facilities, certain oceanographic vessels and Antarctic research stations. The Foundation also supports cooperative research between universities and industry, US participation in international scientific and engineering efforts, and educational activities at every academic level.

Facilitation Awards for Scientists and Engineers with Disabilities provide funding for special assistance or equipment to enable persons with disabilities to work on NSF-supported projects. See Grant Proposal Guide Chapter II, Section D.2 for instructions regarding preparation of these types of proposals.

The National Science Foundation has Telephonic Device for the Deaf (TDD) and Federal Information Relay Service (FIRS) capabilities that enable individuals with hearing impairments to communicate with the Foundation about NSF programs, employment or general information. TDD may be accessed at (703) 292-5090 and (800) 281-8749, FIRS at (800) 877-8339.

The National Science Foundation Information Center may be reached at (703) 292-5111.

ABOUT THE NATIONAL INSTITUTES OF HEALTH

The National Institutes of Health (NIH) mission is to uncover new knowledge that will lead to better health for everyone. NIH works toward that mission by conducting research in its own laboratories; supporting the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helping in the training of research investigators; and fostering communication of medical information. The NIH institutes and centers participating in this program contribute to NIH's mission through research efforts aimed at understanding, treating, and preventing disease states that involve or are related to the nervous system.

• The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. NINDS supports research projects that range from basic studies of the nervous system to Phase III clinical trials. Through the CRCNS program, NINDS will not support definitive clinical trials of therapeutic devices, such as a traditional feasibility study and/or pivotal trial (see http://www.fda.gov/downloads/MedicalDevices/DeviceRegulati%20onandGuidance/GuidanceDocuments/UCM279103.pdf2 for the definition of an early feasibility study, feasibility study and pivotal trial). The NINDS is interested in supporting collaborative research in innovative computational analysis, simulation and modeling of physiological and pathological structures and functions of the nervous system, and mechanisms underlying neurological neuromuscular and neurovascular disorders.
• The mission on NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. NIMH supports research programs in neuroscience and basic behavioral science, genomics, technology development, translational research, global mental health, and services and intervention. The NIMH Strategic Plan for Research provides a broad roadmap for the Institute’s research priorities, encompassing a range from fundamental science of the brain and behavior to public health impact. For specifics about the NIMH strategic plan for research, please see: http://www.nimh.nih.gov/research-priorities/index.shtml.
• NIDA supported research is aimed at increasing the understanding of the causes and consequences of drug abuse and addiction. NIDA supports a broad research program in basic and clinical research, neuroscience, molecular biology, genetics, epidemiology, behavioral sciences and services research.
• NEI supports basic and clinical research aimed at increasing our understanding of the eye and the visual system in normal health and disease.
• NIDCD supports biomedical and behavioral research related to normal and disordered processes of hearing, balance, smell, taste, voice, speech and language. Basic and clinical studies of genetic, molecular, cellular, physiological, biochemical, and behavioral aspects of function in health and disease are encouraged.
• NIBIB supports research and development of new and novel computational methods for modeling, simulation and analysis for the purpose of detecting, treating and preventing disease. For projects developing computational methods for image analysis and post-processing, where the computation is not linked to the direct testing or generation of a neuroscience hypothesis, please refer to the NIBIB program for image processing:
  http://www.nibib.nih.gov/Research/ProgramAreas/ImageProcessing.
• NIAAA supports basic, clinical and behavioral research to increase the understanding of normal and abnormal biological functions and behavior relating to alcohol use, to improve the diagnosis, prevention, and treatment of alcohol use disorders, and to enhance quality health care to reduce the burden of alcohol abuse and addiction.
• NICHD supports the full spectrum of basic, clinical, and translational research in the biomedical and behavioral neuroscience arenas, particularly as they affect developing systems and rehabilitation
• NCCIH supports research using scientific methods and advanced technologies (e.g., fMRI) to study a diverse array of complementary medical and health care systems, practices (e.g., mindfulness-based stress reduction) and natural products with the goal of understanding their potential contribution to health, well-being, and symptom management. Inclusive in this goal is to support collaborative computational, genetic, molecular, and biological and behavioral based approaches that can be combined and brought to bear on understanding the underlying mechanisms of action of these complementary practices and products.

For the latest information about NIH programs, visit the NIH website at http://www.nih.gov/.

ABOUT THE FEDERAL MINISTRY OF EDUCATION AND RESEARCH

Research and development in areas such as chemistry and materials science, semiconductors, laser and plasma technology together with the latest production processes are the basis for new technological developments of tomorrow. The Federal Ministry of Education and Research (BMBF) provides financial support for innovative projects and ideas under targeted research funding programmes.

The range covers everything from basic scientific research, environmentally friendly sustainable development, new technologies, information and communication technologies, the life sciences, work design; structural research funding at institutions of higher education to innovation support and technology transfer.

Research funding supports scientific institutions and enterprises. The BMBF also funds individual researchers via special funding institutions.

ABOUT THE FRENCH NATIONAL RESEARCH AGENCY

The French National Research Agency is a public organization devoted to competitive project-base funding in both fundamental and applied research. Its objectives are to promote creativity, to bring more flexibility and, subsequently, reactivity and to increase competitiveness while maintaining a good balance between fundamental research and applied research. It funds all science and technology areas.

ABOUT THE U.S.-ISRAEL BINATIONAL SCIENCE FOUNDATION

The U.S.-Israel Binational Science Foundation (BSF) promotes scientific relations between the U.S. and Israel by supporting collaborative research projects in a wide area of basic and applied scientific fields, for peaceful and non-profit purposes. The foundation is owned equally by the two governments, and financed by endowments created by both governments. The BSF is an independent organization, and is governed by a board of governors consisting of equal numbers of U.S. and Israeli members. Since its creation in 1972, it has supported over 5000 joint U.S.-Israeli research projects. 43 Nobel Laureates have participated in BSF supported projects.

The National Science Foundation promotes and advances scientific progress in the United States by competitively awarding grants and cooperative agreements for research and education in the sciences, mathematics, and engineering. To get the latest information about program deadlines, to download copies of NSF publications, and to access abstracts of awards, visit the NSF Website at https://www.nsf.gov Location: 4201 Wilson Blvd. Arlington, VA 22230 For General Information (NSF Information Center): (703) 292-5111 TDD (for the hearing-impaired): (703) 292-5090 To Order Publications or Forms: Send an e-mail to: nsfpubs@nsf.gov or telephone: (703) 292-7827 To Locate NSF Employees: (703) 292-5111

Privacy Act And Public Burden Statements

The information requested on proposal forms and project reports is solicited under the authority of the National Science Foundation Act of 1950, as amended. The information on proposal forms will be used in connection with the selection of qualified proposals; and project reports submitted by awardees will be used for program evaluation and reporting within the Executive Branch and to Congress. The information requested may be disclosed to qualified reviewers and staff assistants as part of the proposal review process; to proposer institutions/grantees to provide or obtain data regarding the proposal review process, award decisions, or the administration of awards; to government contractors, experts, volunteers and researchers and educators as necessary to complete assigned work; to other government agencies or other entities needing information regarding applicants or nominees as part of a joint application review process, or in order to coordinate programs or policy; and to another Federal agency, court, or party in a court or Federal administrative proceeding if the government is a party. Information about Principal Investigators may be added to the Reviewer file and used to select potential candidates to serve as peer reviewers or advisory committee members. See Systems of Records, NSF-50, "Principal Investigator/Proposal File and Associated Records," 69 Federal Register 26410 (May 12, 2004), and NSF-51, "Reviewer/Proposal File and Associated Records," 69 Federal Register 26410 (May 12, 2004). Submission of the information is voluntary. Failure to provide full and complete information, however, may reduce the possibility of receiving an award.

An agency may not conduct or sponsor, and a person is not required to respond to, an information collection unless it displays a valid Office of Management and Budget (OMB) control number. The OMB control number for this collection is 3145-0058. Public reporting burden for this collection of information is estimated to average 120 hours per response, including the time for reviewing instructions. Send comments regarding the burden estimate and any other aspect of this collection of information, including suggestions for reducing this burden, to:

Suzanne H. Plimpton
Reports Clearance Officer
Office of the General Counsel
National Science Foundation
Arlington, VA 22230