Cellular and Biochemical Engineering (CBE)

The Cellular and Biochemical Engineering program is part of the Engineering Biology and Health cluster, which includes also 1) Engineering of Biomedical Systems; 2) Biophotonics; 3) Nano-Biosensing; and 4) Disability and Rehabilitation Engineering.

The Cellular and Biochemical Engineering (CBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical and biotechnology industries.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the CBE program. 

Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in the biomanufacturing environment, and how those molecular-level interactions lead to changes in structure, function, and behavior.  The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

Major areas of interest in the program include:

• Metabolic engineering and synthetic biology for biomanufacturing 
• Quantitative systems biotechnology
• Cell culture technologies
• Protein and enzyme engineering
• Single cell dynamics and modeling in the context of biomanufacturing
• Development of novel "omics" tools for biomanufacturing applications

All applications should include a description on the potential impact of proposed research on the associated biomanufacturing process.  Proposals whose core innovation is tissue engineering or organ culture should be submitted to the Engineering of Biomedical Systems program (5345). 

The duration of unsolicited awards is generally one to three years. The typical award size for the program is around $100,000 per year with allowance for up to $200,000 per year for collaborative projects or those involving multiple investigators.  Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review.

INFORMATION COMMON TO MOST CBET PROGRAMS

Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field.  Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.  The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal.

Faculty Early Career Development (CAREER) program proposals are strongly encouraged.  Award duration is five years.  The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URL here for more information. 

Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal.

Grants for Rapid Response Research (RAPID) and Early-concept Grants for Exploratory Research (EAGER) are also considered when appropriate.  Please note that proposals of these types must be discussed with the program director before submission.  Further details are available in the Proposal and Award Policies and Procedures Guide (PAPPG) download found here.  Grant Opportunities for Academic Liaison with Industry (GOALI) proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged.  Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be found here.

COMPLIANCE: Proposals which are not compliant with the Proposal and Award Policies and Procedures Guide (PAPPG) will be returned without review.

Unsolicited proposals received outside of the Announced Proposal Window dates will be returned without review.