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Cellular and Biochemical Engineering (CBE)

Status: Archived

Archived funding opportunity

This document has been archived. See PD 23-1491 for the latest version.

Important information about NSF’s implementation of the revised 2 CFR

NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website. These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.

Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Synopsis

The Cellular and Biochemical Engineering (CBE) program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems.

The Cellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular and biomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries.

Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. 

The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

Major areas of interest in the program include:

  • Metabolic engineering and synthetic biology for biomanufacturing, including the design of synthetic metabolic components and synthetic cells, 
  • Quantitative systems biotechnology,
  • Cell culture technologies,
  • Protein and enzyme engineering, and
  • Single cell dynamics and modeling in the context of biomanufacturing.

All proposals should include a description on the potential impact of proposed research on an associated biomanufacturing process. Proposals whose core innovation involves tissue engineering or organ culture should be submitted to the Engineering of Biomedical Systems program (5345). 

The duration of unsolicited awards is generally one to three years. The typical award size for the program is around $100,000 per year with allowance for up to $200,000 per year for collaborative projects involving multiple institutions. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review.

 

INFORMATION COMMON TO MOST CBET PROGRAMS

Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field.  Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry.  The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal.

Faculty Early Career Development (CAREER) program proposals are strongly encouraged.  Award duration is five years.  The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URL here for more information. 

Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal.

Grants for Rapid Response Research (RAPID) and EArly-concept Grants for Exploratory Research (EAGER) are also considered when appropriate.  Please note that proposals of these types must be discussed with the program director before submission.  Further details are available in the Proposal and Award Policies and Procedures Guide (PAPPG) download found here.  Grant Opportunities for Academic Liaison with Industry (GOALI) proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged.  Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be found here.

COMPLIANCE: Proposals which are not compliant with the Proposal and Award Policies and Procedures Guide (PAPPG) will be returned without review.

 

 

Program contacts

Steven W. Peretti
speretti@nsf.gov (703) 292-7029 ENG/CBET

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