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Enabling Discovery through GEnomics (EDGE)

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NSF 21-546

Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Supports the development of genomic tools and research to uncover the relationships between genes and phenotypes across environmental, developmental, social and genomic contexts.

Supports the development of genomic tools and research to uncover the relationships between genes and phenotypes across environmental, developmental, social and genomic contexts.


Through the Enabling Discovery through GEnomics (EDGE) program, the National Science Foundation (NSF) and the National Institutes for Health (NIH) support research to advance understanding of comparative and functional genomics.  The EDGE program supports the development of innovative tools, technologies, resources, and infrastructure that advance biological research focused on the identification of the causal mechanisms connecting genes and phenotypes. The EDGE program also supports functional genomic research that addresses the mechanistic basis of complex traits in diverse organisms within the context (environmental, developmental, social, and/or genomic) in which they function.  These goals are essential to uncovering the rules that underlie genomes-to-phenomes relationships and predict phenotype, an area relevant to Understanding the Rules of Life: Predicting Phenotype, one of the 10 Big Ideas for NSF investment.  The goals also support the NHGRI priority to establish the roles and relationships of all genes and regulatory elements in pathways, networks, and phenotypes.

Program contacts

General inquiries regarding this program should be made to:


For questions about NHGRI interests, contact:

  • Alexander Arguello, telephone (301) 402-2963, email: alexander.arguello@nih.gov

National Human Genome Research Institute (NHGRI) 

NHGRI will support the development of resources, approaches, and technologies that will accelerate genomic research on the structure of genomes, the biology of genomes, and the biology of disease; that will use genomics to advance the science of medicine; and that will incorporate genomics to improve the effectiveness of healthcare. NHGRI will also support genomic research in several cross-cutting areas, including the ethical, legal and societal implications of genomics and genetics research, bioinformatics, technology development, and research training and career development.

In general, NHGRI supports studies that provide generalizable methods and knowledge.  Applications for studies relevant only to a particular disease or organ system should be directed to the appropriate Institute or Center. NHGRI strongly encourages potential applicants to contact program staff in the early stages of developing your application. The contact information for the three scientific programs are:

Division of Genome Science: https://www.genome.gov/27550609/division-of-genome-sciences-staff/  

Division of Genomic Medicine: https://www.genome.gov/27550610/division-of-genomic-medicine-staff/

Division of Genomics and Society: https://www.genome.gov/27550080/division-of-genomics-and-society/

Theodore J. Morgan
tmorgan@nsf.gov (703) 292 7868 BIO/IOS
Matthew Fujita
mfujita@nsf.gov (703) 292-7814 BIO/DEB
Courtney E. Jahn
cjahn@nsf.gov (703) 292-7746 BIO/IOS
Susan Renn
srenn@nsf.gov (703) 292-2260 BIO/IOS
Clifford Weil
cweil@nsf.gov (703) 292-4668 BIO/MCB
Alexander Arguello
alexander.arguello@nih.gov (301) 402-2963
Kris Wetterstrand
wettersk@mail.nih.gov (301) 435-5543

Awards made through this program

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