The Genetic Mechanisms (GM) cluster seeks inventive ideas and research to address fundamental questions about genetics, epigenetics, and gene expression mechanisms in diverse organisms. The cluster encourages cross-disciplinary and collaborative research, especially employing perspectives and approaches from computational, mathematical, chemical, and physical sciences and engineering. Creative tool development to address new or long-standing questions about genetic mechanisms is welcome. Primarily descriptive projects are given lower priority.
The cluster encourages research on predictive understanding of:
- The spatiotemporal organization, coordination and/or regulation of processes that maintain, replicate, transcribe and translate the genome;
- Relationships between genomic or epigenomic determinants and molecular or cellular phenotypes;
- Transcriptomic, epitranscriptomic, and other RNA-based regulatory mechanisms;
- Structure-function relationships, interactions, and reactions of macromolecules involved in genetic and epigenetic processes; and
- Mechanisms of evolution of genes and genomes.
Investigators are encouraged to contact GM Program Directors with project ideas or to seek any further information.