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Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Supports research on the fundamental mechanisms involved in the organization, dynamics, processing, expression, regulation and evolution of genetic and epigenetic information.


The Genetic Mechanisms (GM) cluster seeks inventive ideas and research to address fundamental questions about genetics, epigenetics, and gene expression mechanisms in diverse organisms. The cluster encourages cross-disciplinary and collaborative research, especially employing perspectives and approaches from computational, mathematical, chemical, and physical sciences and engineering. Creative tool development to address new or long-standing questions about genetic mechanisms is welcome. Primarily descriptive projects are given lower priority.

The cluster encourages research on predictive understanding of:

  • The spatiotemporal organization, coordination and/or regulation of processes that maintain, replicate, transcribe and translate the genome;
  • Relationships between genomic or epigenomic determinants and molecular or cellular phenotypes;
  • Transcriptomic, epitranscriptomic, and other RNA-based regulatory mechanisms;
  • Structure-function relationships, interactions, and reactions of macromolecules involved in genetic and epigenetic processes; and
  • Mechanisms of evolution of genes and genomes.

Investigators are encouraged to contact GM Program Directors with project ideas or to seek any further information.

Program contacts

Manju Hingorani
mhingora@nsf.gov 703-292-7323 BIO/MCB
Stephen DiFazio
sdifazio@nsf.gov (703) 292-4517 BIO/MCB
Arcady R. Mushegian
amushegi@nsf.gov (703) 292-8528 BIO/MCB
Clifford Weil
cweil@nsf.gov (703) 292-8712 BIO/MCB

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