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Important Information for Proposers

Any proposal submitted in response to this funding opportunity should be submitted in accordance with the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. The NSF PAPPG is regularly revised and it is the responsibility of the proposer to ensure that the proposal meets the requirements specified in this solicitation and the applicable version of the PAPPG. Submitting a proposal prior to a specified deadline does not negate this requirement.

Supports mechanistic, computational and evolutionary research in neuroscience that spans multiple levels of analysis, ranging from the molecular and cellular to the complex behavioral aspects of organisms.


The Neural Systems Cluster supports mechanistic studies in neuroscience that span multiple levels of analysis ranging from the molecular and cellular to the complex behavioral aspects of organisms.  The Cluster encourages the use of comparative approaches, studies of organisms in their natural contexts, and the development of novel theoretical, computational, and transdisciplinary approaches to guide and instruct experimental design. 

Proposals should be submitted to one of the three programs below:  

The Organization Program (Program Code: 7712; Andrea Holgado, (703) 292-7076, aholgado@nsf.gov) supports research on how the nervous system is organized along developmental, genetic, molecular, and cellular lines; explorations of developmental mechanisms; and how experiential/environmental interactions affect basic structural and functional characteristics of the nervous system.

The Activation Program (Program Code: 7713; Quentin Gaudry, (703) 292-2903, Qgaudry@nsf.gov) supports research focused on how signals from the external environment activate the nervous system, and how the nervous system integrates sensorimotor responses to trigger an action. 

The Modulation Program (Program Code: 7714; Edda Floh Thiels, (703) 292-8167, ethiels@nsf.gov; Kathleen Lynch, (703) 292-2095, klynch@nsf.gov) supports research focused on mechanisms mediating organism-environment interactions, including, but not limited to, synaptic, circuit, and behavioral plasticity; social and emotional regulation of behaviors; neuroendocrine and neuroimmune function; biological rhythms and other complex functions.

Program contacts

For general inquiries about the Neural Systems Cluster you may contact us at IOSNSC@nsf.gov or at (703) 292-8421.

Edda Floh Thiels
ethiels@nsf.gov (703) 292-8167 BIO/IOS
Quentin Gaudry
qgaudry@nsf.gov (703) 292-2903 BIO/IOS
Andrea Holgado de Brigueda
Program Director
aholgado@nsf.gov (703) 292-7076 BIO/DBI
Kathleen Lynch
klynch@nsf.gov (703) 292-2095 BIO/IOS

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