Abstract collage of science-related imagery

BioFoundries to Enable Access to Infrastructure and Resources for Advancing Modern Biology and Biotechnology (BioFoundries)

View guidelines

NSF 23-585

Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Supports establishment of biofoundries to catalyze understanding of biological or bio-engineered systems, while ensuring broad access to technologies, training and education, and enabling rapid translation of basic discoveries.

Supports establishment of biofoundries to catalyze understanding of biological or bio-engineered systems, while ensuring broad access to technologies, training and education, and enabling rapid translation of basic discoveries.


Grand challenge questions requiring a deeper understanding of biological systems and technologies are as diverse as life itself. Understanding the complexity of living systems and their interactions with human-derived products and processes, ensuring the safe, ethical and equitable access to and co-generation of knowledge and products,  requires the sustained development of technologies, sophisticated instrumentation, workflow pipelines and their automation, and advanced computing that are beyond the capabilities found in the laboratories of individual investigators. Broad access to these tools, workflows, processes, and knowledge bases in a facility that is capable of bespoke design and process scale-up, in response to user needs, is essential for addressing grand challenges and translating the knowledge created into applications for the bioeconomy, to meet societal and national needs.

BioFoundries is an infrastructure program from the National Science Foundation (NSF) that is designed to accelerate advances in the biological sciences, chemical biology, biotechnology, and bioengineering via access to modern infrastructure, technology, and capacity. BioFoundries will provide the intellectual, technical, digital, and physical frameworks needed for tight integration of technology innovations and applications with foundational interdisciplinary research and training, by:

  1. serving as access points for new biological technologies, workflows, processes, automations, and knowledgebases to enable transformative discoveries;
  2. catalyzing new innovations and transformative discoveries by supporting in-house and external user-initiated research programs that take full advantage of technological and methodological advances;
  3. continuing to develop novel technologies, workflows, processes, automations, and knowledgebases that are both forward-looking and user-responsive;
  4. increasing the reproducibility of life science discoveries and data and knowledge sharing capabilities;
  5. training the next generation of the scientific workforce; and
  6. facilitating pathways to translation.  

Leveraging lessons learned from existing national and international biofoundries, NSF encourages researchers to consider a diversity of models (centralized, distributed, consortium) in the design and implementation of BioFoundries. Each BioFoundry should enclose a scientific ecosystem, that includes in-house research scientists across all relevant disciplines supported by NSF, technical staff including cyberinfrastructure experts, external users, and other contributors who, collectively, form a community of practitioners and share tools, reagents, workflows, software, samples, and data. Knowledge sharing should be a central tenet, designed to strengthen collaborations among researchers and enable them to work in new ways and to foster new modalities of research and education/training, for the purpose of accelerating discovery and advancing development.  BioFoundries should promote diversity, equity, inclusion, and accessibility in their in-house programs and external user programs.  BioFoundries should also promote new avenues for translating such knowledge and technology broadly in ways that benefit society. 

Program contacts

Sridhar Raghavachari
Program Director, BIO/DBI
sraghava@nsf.gov (703) 292-4845 BIO/DBI
Anthony G. Garza
Program Director, BIO/MCB
aggarza@nsf.gov (703) 292-8440 BIO/MCB
Steven W. Peretti
Program Director, ENG/CBET
speretti@nsf.gov (703) 292-4201 ENG/CBET
Laurel C. Kuxhaus
Program Director, ENG/CMMI
lkuxhaus@nsf.gov (703) 292-4465
Mitra Basu
Program Director, CISE/CCF
mbasu@nsf.gov (703) 292-8649 CISE/CCF
Vladimir Pavlovic
Program Director, CISE/IIS
vpavlovi@nsf.gov (703) 292-8318 CISE/IIS
Gregory Collins
Program Director, MPS/CHE
grcollin@nsf.gov (703) 292-7064 MPS/CHE
Z. Charles Ying
Program Director, MPS/DMR
cying@nsf.gov (703) 292-8428 MPS/DMR
Ruth M. Shuman
Program Director, TIP/TI
rshuman@nsf.gov (703) 292-2160 TIP/TI
Alberto Perez-Huerta
Program Director, GEO/EAR
aperezhu@nsf.gov 703 292 8500 GEO/EAR
Lee D. Walker
Program Director, SBE/SES
lwalker@nsf.gov (703) 292-7174 SBE/SES
Dwight Kravitz
Program Director, SBE/BCS
dkravitz@nsf.gov (703) 292-4502 SBE/BCS
John-David Swanson
Program Director, OD/OIA
jswanson@nsf.gov (703) 292-2898 OD/OIA

Awards made through this program

Browse projects funded by this program
Map of recent awards made through this program