Chemistry of Life Processes (CLP)

The Chemistry of Life Processes (CLP) Program supports fundamental experimental and computational studies at the interface of chemistry and biology. Such studies would promote the fundamental understanding of the molecular underpinnings of life processes.  The proposed research should be based on innovation(s) in chemistry and address an important question about a biological process.

The scope of the program is broad, reflecting the power of chemistry and diversity of biology.  Subject areas include bioorganic and bioinorganic chemistry; chemical biology; lipids, membranes and membrane-proteins; and protein, enzyme, nucleic acid and carbohydrate chemistry. Research projects must use or create innovations in chemistry that advance the understanding of biological function.  Chemical methods development is also acceptable when such methods are applied to answering specific biological questions.  Other topics of interest include:  the development and application of bio-orthogonal chemistry for probing cellular function; biomolecular design and synthesis aimed at understanding biological function; the use of theory, computation, modeling and simulation as applied to the chemical aspects of biological systems; and chemical aspects that underlie the function of the brain. 

Note: The CLP Program is not interested in projects that are disease-related or that have drug discovery/design/development goals. PIs uncertain of the suitability of their proposals are encouraged to contact a CLP Program Officer.

Submissions that address national needs are encouraged.  Of particular interest are the priority areas associated with NSF's Ten Big Ideas.  Elements particularly relevant to the Division of Chemistry include: Harnessing the Data Revolution, the Quantum Leap, Midscale Instrumentation, Understanding the Rules of Life, and Growing Convergence Research at NSF.  Consult Chemistry's Dear Colleague Letter compilation for Division-specific guidance on how these areas match the Division's portfolio.