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Division of Molecular and Cellular Biosciences: Investigator-initiated research projects

Status: Archived

Archived funding opportunity

This document has been archived. See NSF 24-539 for the latest version.

Important information about NSF’s implementation of the revised 2 CFR

NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website. These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.

Important information for proposers

All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements. Submitting a proposal prior to a specified deadline does not negate this requirement.

Synopsis

The Division of Molecular and Cellular Biosciences (MCB) supports quantitative, mechanistic, predictive, and theory-driven fundamental research designed to promote understanding of complex living systems at the molecular, subcellular, and cellular levels. While recognizing the need for thorough and accurate descriptions of biological complexes and pathways, the priority of the Division is to support work that advances the field by capturing the predictive power of mechanistic, quantitative, and evolutionary approaches.

Two funding tracks will be available. 

  • Core Program Track proposals are solicited to support research relevant to the four MCB core clusters:

             o   Cellular Dynamics and Function

             o   Genetic Mechanisms

             o   Molecular Biophysics

             o   Systems and Synthetic Biology

  • Rules of Life Track proposals that integrate across the scales in biological sciences are solicited to support research that spans from the molecular and cellular levels normally funded by MCB to organismal and ecosystem scales typically funded by other divisions in the Biological Sciences.  This track provides new opportunities to advance our understanding of the Rules of Life by new mechanisms for review and funding of proposals that would not ordinarily fit well within one division in the Biological Sciences Directorate.

MCB gives high priority to research projects that use theory, methods, and technologies from life and physical sciences, mathematics, computational sciences, and engineering to address major biological questions that elucidate the rules governing subcellular and cellular processes.  Research supported by MCB uses a range of experimental and computational approaches--including in vivo, in vitro and in silico strategies--and a broad spectrum of model and non-model organisms, including microbes and plants. Typical research supported by MCB integrates theory and experimentation. Projects are particularly welcome that address the emerging areas of: multi-scale integration; transformative methods and resources (when driven by compelling biological questions); molecular and cellular evolution; the synthesis of life-like systems; and the quantitative prediction of the phenome from genomic information. Highest funding priority is given to applications that have outstanding intellectual merit and strong broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive.  Proposals that are motivated by relevance to human health and disease treatment are not appropriate for the Division and will be returned without review.

Program contacts

Charles Cunningham
Cellular Dynamics and Function
mcb-cdf@nsf.gov (703) 292-8440 BIO/MCB
Arcady Mushegian
Genetic Mechanisms
mcb-gm@nsf.gov (703) 292-8440 BIO/MCB
Wilson A. Francisco
Molecular Biophysics
mcb-mb@nsf.gov (703) 292-8440 BIO/MCB
David A. Rockcliffe
Systems and Synthetic Biology
mcb-ssb@nsf.gov (703) 292-8440 BIO/MCB

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